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the forum for Advanced Drug Discussion and the best Repository for information about psychoactives and journal articles that anyone can edit. To start posting, go to Blacklight Forums or check out Blacklight's Repository- it currently has
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Today's News

Feds Raid Medical Marijuana Facilities in Montana
ALERT: DEA Emergency Schedules Five Synthetic Cannabinoids
Lee County Stores Get Rid of 'Fake Pot' Stashes
A Conversation with Terry Goddard, Atty Gen. of Arizona

Another Random Entry ...


A receptor antagonist is a type of receptor ligand or drug that does not provoke a biological response itself upon binding to a receptor, but blocks or dampens agonist-mediated responses.[1] In pharmacology, antagonists have affinity but no efficacy for their cognate receptors and binding will disrupt the interaction and inhibit the function of an agonist or inverse agonist at receptors. Antagonists mediate their effects by binding to the active site or to allosteric sites on receptors or they may interact at unique binding sites not normally involved in the biological regulation of the receptor's activity. Antagonist activity may be reversible or irreversible depending on the longevity of the antagonist–receptor complex which in turn depends on the nature of antagonist receptor binding. The majority of drug antagonists achieve their potency by competing with endogenous ligands or substrates at structurally defined binding sites on receptors.